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dc.contributor.authorAydın, Zeki
dc.contributor.authorYılmaz, Mürvet
dc.contributor.authorSipahioğlu, Murat
dc.contributor.authorDervişoğlu, Erkan
dc.contributor.authorAydemir, Nihal
dc.contributor.authorUzun, Sami
dc.contributor.authorİstemihan, Zülal
dc.contributor.authorÜnsal, Oktay
dc.contributor.authorTatar, Erhan
dc.contributor.authorBerktaş, Hacı Bayram
dc.contributor.authorÖzdemir, Arzu
dc.contributor.authorSumnu, Abdullah
dc.contributor.authorKumru, Gizem
dc.contributor.authorÇetinkaya, Hakkı
dc.contributor.authorKazan, Sinan
dc.contributor.authorKoçyiğit, İsmail
dc.contributor.authorGökalp, Cenk
dc.contributor.authorHasbal, Barış
dc.contributor.authorArtan, Ayşe Serra
dc.contributor.authorÖzelsancak, Rüya
dc.contributor.authorTaymez, Dilek
dc.contributor.authorYadigar, Serap
dc.contributor.authorAlagöz, Selma
dc.contributor.authorAslan, Bilal Burçak
dc.contributor.authorYaylacı, Selçuk
dc.contributor.authorJabrayilov, Jabrayil
dc.contributor.authorTurgutalp, Kenan
dc.contributor.authorDursun, Belda
dc.contributor.authorŞahin, Garip
dc.identifier.citationAydin, Z., Yilmaz, M., Sipahioglu, M., Dervisoglu, E., Aydemir, N., Uzun, S., ... & Sahin, G. (2022). Demographic, Clinical and Laboratory Characteristics of Adult-Onset Minimal Change Disease in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group.en_US
dc.description.abstractPurpose In our study, diagnostic and demographic characteristics of patients diagnosed with minimal change disease (MCD) by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. The data presented are cross-sectional and includes application data for the biopsy period. Results Of 3875 patients, 233 patients with MCD (median age 35.0 years) were included in the study, which constitutes 6.0% of the total glomerulonephritis database. Renal biopsy was performed in 196 (84.1%) patients due to nephrotic syndrome. Median serum creatinine was 0.7 (0.6–1.0) mg/dl, mean eGFR was 104 ± 33 ml/min/1.73 m2 and median proteinuria 6000 mg/day. The number of patients under the age of 40 years was 139 (59.7%) (Group A), and the number of patients aged 40 years and over was 94 (40.3%) (Group B). Compared to Group A, global sclerotic glomeruli (24 vs. 43, p < 0.001) interstitial inflammation (15 vs. 34, p < 0.001), interstitial fibrosis (20 vs. 31, p = 0.001, vascular changes (10 vs. 25, p < 0.001) and tubular atrophy (18 vs. 30, p < 0.001) were found to be significantly higher in Group B. There was no difference in immunofluorescent staining properties between the two groups. Conclusion Our data are generally compatible with the literature. Chronic histopathological changes were more common in patients aged 40 years and older than younger patients. Studies investigating the effects of these different features on renal survival are needed.en_US
dc.subjectMinimal change diseaseen_US
dc.subjectNephrotic syndromeen_US
dc.subjectPrimary glomerular diseasesen_US
dc.titleDemographic, clinical and laboratory characteristics of adult-onset minimal change disease in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Groupen_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorKazan, Sinan
dc.relation.journalInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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