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dc.contributor.authorBilir, Abdulkadir
dc.contributor.authorAtay, Emre
dc.contributor.authorFırat, Fatma
dc.contributor.authorKundakçı, Yunus Emre
dc.date.accessioned2022-09-19T06:39:31Z
dc.date.available2022-09-19T06:39:31Z
dc.date.issued10.08.2022en_US
dc.identifier.citationBilir, A., Atay, E., Firat, F., & Kundakci, Y. E. (2022). Investigation of developmental toxicity of favipiravir on fetal bone and embryonic development. Birth Defects Research.en_US
dc.identifier.issn2472-1727
dc.identifier.urihttps://doi.org/10.1002/bdr2.2073
dc.identifier.urihttps://hdl.handle.net/20.500.12933/1417
dc.description.abstractBackground Favipiravir is one of the essential antiviral drugs used for the treatment of coronavirus disease (COVID-19) in some countries. However, there is not enough information about used, especially in pregnancy. Therefore, in this study, it was aimed to determine the developmental toxicity of favipiravir on fetal bone development and embryonic development. Methods In this study, 16 pregnant wistar albino rats were used. The rats were divided into four groups: Control (saline) and Group A (50 mg/kg × 5 days), Group B (50 mg/kg × 1 days + 20 mg/kg × 4 days), Group C (20 mg/kg × 5 days). Solutions were administered to the rats by oral gavage from the 10th to 14th days of pregnancy, twice a day. The skeletal system development of fetuses was examined with double skeletal staining and immunohistochemical staining methods. Results A total of 72 fetuses from pregnant rats, 18 in each group, were included in the study. As a result, depending on favipiravir dose increase, in experimental groups, it was determined that the statistically significant decrease on the ossification rates of anterior and posterior extremity bones, and length and weight of fetuses. Conclusion Exposure to favipiravir during pregnancy impairs bone metabolism and bone formation-resorption stages and may cause developmental delay.en_US
dc.language.isoengen_US
dc.publisherWileyen_US
dc.relation.isversionof10.1002/bdr2.2073en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDevelopmental toxicityen_US
dc.subjectDouble skeleton stainingen_US
dc.subjectFavipiraviren_US
dc.subjectGrowth retardationen_US
dc.subjectOssificationen_US
dc.titleInvestigation of developmental toxicity of favipiravir on fetal bone and embryonic developmenten_US
dc.typearticleen_US
dc.authorid0000-0003-0633-9542en_US
dc.authorid0000-0002-2378-1183en_US
dc.authorid0000-0003-0027-5138en_US
dc.authorid0000-0002-2006-9940en_US
dc.departmentAFSÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalıen_US
dc.contributor.institutionauthorBilir, Abdulkadir
dc.contributor.institutionauthorAtay, Emre
dc.contributor.institutionauthorFırat, Fatma
dc.contributor.institutionauthorKundakçı, Yunus Emre
dc.identifier.startpage1en_US
dc.identifier.endpage9en_US
dc.relation.journalBirth Defects Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


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