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dc.contributor.authorÇeleğen, Mehmet
dc.contributor.authorÇeleğen, Kübra
dc.date.accessioned2022-09-15T06:21:19Z
dc.date.available2022-09-15T06:21:19Z
dc.date.issued2022en_US
dc.identifier.citationÇeleğen, M., & Çeleğen, K. (2022). Is vasoactive-inotropic score associated with early lactate clearance a predictive outcome of children with septic shock?. The Turkish Journal of Pediatrics, 64(4), 708-716.en_US
dc.identifier.issn2791-6421
dc.identifier.urihttps://doi.org/10.24953/turkjped.2022.170
dc.identifier.urihttps://hdl.handle.net/20.500.12933/1413
dc.description.abstractBackground. The main goal of septic shock therapy is to keep hemodynamic parameters in the normal range for adequate tissue perfusion. Persistent lactic acidemia has increased mortality. We evaluate the association between vasoactive-inotropic score (VIS) and lactate clearance (LC) to predict mortality of septic shock in children. Methods. This is a retrospective study of consecutive septic shock in children admitted to the pediatric intensive care unit. Vital signs, laboratory values, and VIS were obtained at admission and the 6th hour of hospitalization. LC was calculated at the 6th hour. The associations between LC and VIS were evaluated using univariate and multivariate analysis. Receiver operating characteristic analysis was used to describe the cutoff values of LC and VIS. Results. Eighty-two children, age 82.3 ± 59.8 months, were included, with an overall lactate clearance of 29 ± 26%, and a mortality rate of 25.6%. The optimal cutoff value of LC was 20%. Children with LC ≥ 20% compared with LC < 20% had a lower VIS [(21.41 ± 8.36) vs. (27.48 ± 10.11) (p: 0.009)]. In multivariate comparison, PELOD score and VIS were significantly associated with 6-hour lactate clearance < 20% but VIS at 6 hours had a significant inverse relationship with LC < 20%. The cutoff for VIS was ≥ 16.2 for prognosticating the 6-hour LC and the high VIS group had a significantly lower LC and higher mortality ratio than the low VIS group. Conclusions. High VIS was associated with lower lactate clearance and has been described as a predictor of greater mortality among septic shock in children.en_US
dc.language.isoengen_US
dc.publisherHacettepe Medical Centeren_US
dc.relation.isversionof10.24953/turkjped.2022.170en_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLactate clearanceen_US
dc.subjectVasoactive-inotropic scoreen_US
dc.subjectSeptic shocken_US
dc.subjectMortalityen_US
dc.subjectPediatricen_US
dc.titleIs vasoactive-inotropic score associated with early lactate clearance a predictive outcome of children with septic shock?en_US
dc.typearticleen_US
dc.authorid0000-0002-6841-3675en_US
dc.authorid0000-0003-2178-2788en_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorÇeleğen, Mehmet
dc.contributor.institutionauthorÇeleğen, Kübra
dc.identifier.volume64en_US
dc.identifier.issue4en_US
dc.identifier.startpage708en_US
dc.identifier.endpage716en_US
dc.relation.journalThe Turkish Journal of Pediatricsen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


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