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dc.contributor.authorAkdoğan, Müberra
dc.contributor.authorDoğan, Mustafa
dc.contributor.authorBeysel, Selvihan
dc.contributor.authorGobeka, Hamidu Hamisi
dc.contributor.authorSabaner, Mehmet Cem
dc.contributor.authorOran, Merve
dc.identifier.citationAkdogan, M., Dogan, M., Beysel, S., Gobeka, H. H., Sabaner, M. C., & Oran, M. (2022). Optical coherence tomography angiography characteristics of the retinal and optic disc morphology in prolactinoma. Microvascular Research, 104424.en_US
dc.description.abstractPurpose To investigate changes in the retinal and optic disc (OD) morphology in prolactinoma patients without optical chiasmal compression and/or visual field defects using optical coherence tomography angiography (OCTA). Methods In this cross-sectional imaging study, 16 consecutive prolactinoma patients (group 1, 32 eyes) and 15 age- and gender-matched healthy subjects (group 2, 30 eyes) underwent a thorough neuro-ophthalmological examination, which included testing for the presence of any intracranial compressive lesion that could cause optic neuropathy. Retinal morphological parameters, outer retinal and choriocapillaris flow areas, as well as OD vessel density (VD) and retinal nerve fiber layer (RNFL) thickness in for quadrants were then measured using OCTA. Results Mean age (p = 0.537) and gender (p = 0.385) of participants in groups 1 and 2 did not differ significantly. The mean BCVA for both groups was 0.00 ± 0.00 logMAR. Microadenomas made up the majority of prolactinomas (87.1 %). All retinal morphological parameters in deep capillary plexus (excluding foveal VD) differed significantly between groups 1 and 2 (whole: p < 0.001, parafoveal: p = 0.021, and perifoveal: p < 0.001). Peripapillary RNFL thickness in temporal (p < 0.001), nasal (p = 0.010), and inferior (p = 0.007) quadrants also differed significantly between the two groups. Foveal deep (r = −0.304, p = 0.035) and choriocapillaris flow (r = −0.511, p = 0.008) were negatively correlated with tumor size at diagnosis. Conclusions Significant microvascular morphological changes, particularly in the deep retinal layer, as well as in the peripapillary RNFL thickness, were observed in prolactinoma patients. OCTA appears to be capable of detecting non-manifest circumpapillary and even intra-retinal microvascular changes even when there are no obvious signs of prolactinoma-related ocular complications caused by chiasmal compression.en_US
dc.subjectMorphologyOptic discen_US
dc.subjectOptical coherence tomography angiographyen_US
dc.subjectRetinal microvasculatureen_US
dc.subjectRetinal nerve fiber layeren_US
dc.titleOptical coherence tomography angiography characteristics of the retinal and optic disc morphology in prolactinomaen_US
dc.departmentAFSÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorAkdoğan, Müberra
dc.contributor.institutionauthorDoğan, Mustafa
dc.contributor.institutionauthorBeysel, Selvihan
dc.contributor.institutionauthorGobeka, Hamidu Hamisi
dc.contributor.institutionauthorSabaner, Mehmet Cem
dc.contributor.institutionauthorOran, Merve
dc.relation.journalMicrovascular Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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