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dc.contributor.authorDuman, Murat
dc.contributor.authorŞık, Nihan
dc.contributor.authorTekşam, Özlem
dc.contributor.authorAkça, Halise
dc.contributor.authorKurt, Funda
dc.contributor.authorAkca Çağlar, Ayla
dc.contributor.authorAkcan Yıldız, Leman
dc.contributor.authorTaşar, Medine Ayşin
dc.contributor.authorFidancı, İlknur
dc.contributor.authorCura Yayla, Burcu Ceylan
dc.contributor.authorYılmaz, Durgül
dc.contributor.authorGüngör, Emre
dc.contributor.authorDemir, Şule
dc.contributor.authorÇokuğraş, Haluk
dc.contributor.authorOral Cebeci, Sinem
dc.contributor.authorÖnal, Pınar
dc.contributor.authorUlaş Saz, Eylem
dc.contributor.authorYurtseven, Ali
dc.contributor.authorUysalol, Metin
dc.contributor.authorYıldız, Raif
dc.contributor.authorGümüş, Süheyla
dc.contributor.authorBal, Alkan
dc.contributor.authorŞen Bayturan, Semra
dc.contributor.authorZengin, Neslihan
dc.contributor.authorAtik, Sinem
dc.contributor.authorYılmaz Çiftdoğan, Dilek
dc.contributor.authorBerksoy, Emel
dc.contributor.authorÇiçek, Alper
dc.contributor.authorŞahin, Sabiha
dc.contributor.authorKızıl, Mahmut Can
dc.contributor.authorKara, Yalçın
dc.contributor.authorApa, Hurşit
dc.contributor.authorUlusoy, Emel
dc.contributor.authorAkaslan Kara, Aybüke
dc.contributor.authorYeşil, Edanur
dc.contributor.authorErdem, Meltem
dc.contributor.authorTuran, Caner
dc.contributor.authorArslanoğlu, Sertaç
dc.contributor.authorDuyu, Muhterem
dc.contributor.authorEsen Beşli, Gülser
dc.contributor.authorArslan, Gazi
dc.contributor.authorTolunay Oflu, Ayşe
dc.contributor.authorÇeleğen, Mehmet
dc.contributor.authorBuldu, Ebru
dc.contributor.authorPişkin, İbrahim Etem
dc.contributor.authorKardeş, Hakan
dc.contributor.authorYılmaz, Hayri Levent
dc.contributor.authorYıldızdaş, Dinçer
dc.contributor.authorGökulu, Gamze
dc.contributor.authorÇay, Pınar
dc.contributor.authorÖzer, Utku
dc.contributor.authorDerinöz Güleryüz, Okşan
dc.contributor.authorÇolak, Özlem
dc.contributor.authorTomar Güneysu, Songül
dc.identifier.citationDuman, M., Şık, N., Tekşam, Ö., Akça, H., Kurt, F., Çağlar, A. A., ... & Güneysu, S. T. (2022). COVID-19 disease in children presenting to the pediatric emergency department: A multicenter study with 8886 cases from Turkey. The American Journal of Emergency Medicine.en_US
dc.description.abstractBackground The aim was to evaluate the epidemiological, clinical, laboratory, and radiologic data of children with SARS-CoV-2 positivity by polymerase chain reaction (PCR) together with treatment strategies and clinical outcomes and to evaluate cases of multisystem inflammatory syndrome in children (MIS-C) in this population. Methods This was a multicenter retrospective observational cohort study performed in the pediatric emergency departments of 19 tertiary hospitals. From March 11, 2020, to May 31, 2021, children who were diagnosed with confirmed nasopharyngeal/tracheal specimen SARS-CoV-2 PCR positivity or positivity for serum-specific antibodies against SARS-CoV-2 were included. Demographics, presence of chronic illness, symptoms, history of contact with SARS-CoV-2 PCR-positive individuals, laboratory and radiologic investigations, clinical severity, hospital admissions, and prognosis were recorded. Results A total of 8886 cases were included. While 8799 (99.0%) cases resulted in a diagnosis of SARS-CoV-2 with PCR positivity, 87 (1.0%) patients were diagnosed with MIS-C. Among SARS-CoV-2 PCR-positive patients, 51.0% were male and 8.5% had chronic illnesses. The median age was 11.6 years (IQR: 5.0–15.4) and 737 (8.4%) patients were aged <1 year. Of the patients, 15.5% were asymptomatic. The most common symptoms were fever (48.5%) and cough (30.7%) for all age groups. There was a decrease in the rate of fever as age increased (p < 0.001); the most common age group for this symptom was <1 year with the rate of 69.6%. There was known contact with a SARS-CoV-2 PCR-positive individual in 67.3% of the cases, with household contacts in 71.3% of those cases. In terms of clinical severity, 83 (0.9%) patients were in the severe-critical group. There was hospital admission in 1269 (14.4%) cases, with 106 (1.2%) of those patients being admitted to the pediatric intensive care unit (PICU). Among patients with MIS-C, 60.9% were male and the median age was 6.4 years (IQR: 3.9–10.4). Twelve (13.7%) patients presented with shock. There was hospital admission in 89.7% of these cases, with 29.9% of the patients with MIS-C being admitted to the PICU. Conclusion Most SARS-CoV-2 PCR-positive patients presented with a mild clinical course. Although rare, MIS-C emerges as a serious consequence with frequent PICU admission. Further understanding of the characteristics of COVID-19 disease could provide insights and guide the development of therapeutic strategies for target groups.en_US
dc.titleCOVID-19 disease in children presenting to the pediatric emergency department: A multicenter study with 8886 cases from Turkeyen_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorTolunay Oflu, Ayşe
dc.contributor.institutionauthorÇeleğen, Mehmet
dc.contributor.institutionauthorBuldu, Ebru
dc.relation.journalThe American Journal of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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