Advanced Search

Show simple item record

dc.contributor.authorÇelik Kurt, Zehra Deniz
dc.contributor.authorSönmez, Çiğdem
dc.contributor.authorKaçar, Dilek
dc.contributor.authorEker, İbrahim
dc.contributor.authorBayhan, Turan
dc.contributor.authorYaralı, Neşe
dc.contributor.authorÖzbek, Namık Yaşar
dc.identifier.citationKurt, Z. D. Ç., Sönmez, Ç., Kaçar, D., Eker, İ., Bayhan, T., Yarali, N., & Özbek, N. Y. (2022). Evaluation of coagulation parameters and impact of transfusion on coagulation in patients with beta thalassemia major. Blood Coagulation & Fibrinolysis, 33(5), 266-271.en_US
dc.description.abstractThere have been several studies that have shown that patients with beta thalassemia major are at a higher risk of thrombosis due to the procoagulant activity of thalassemic erythrocytes, decreased liver synthetic function, increased platelet activity and vascular endothelial activation attributed to chronic oxidative stress, although there are no established tests to predict thrombotic risk in TM patients. In this study, we evaluated whether or not the platelet function analyser (PFA-200) and thrombin generation test (TGT) would be useful tools to identify hypercoagulability and risk of thrombosis in thalassemia major patients. The study included 50 patients with thalassemia major and 104 healthy control group. Pretransfusion and posttransfusion PFA-200 and TGT results were compared with control group. We found that median C/ADP and C/EPI values in the thalassemia major group were greater in both the pre and posttransfusion samples than the C/ADP and C/EPI results from the control group. The TGT results showed there was no difference between control group and the results from the thalassemia major group. The TGT and PFA-200 testing did not identify hypercoagulability nor identify clear testing parameters to predict a thalassemia major patient’s risk of thrombosis. There may be other mechanisms/causes yet unidentified that could better explain thalassemia major patient’s increased risk from thromboembolic events.en_US
dc.publisherLippincott, Williams & Wilkinsen_US
dc.subjectPlatelet function analyseren_US
dc.subjectThrombin generation testen_US
dc.titleEvaluation of coagulation parameters and impact of transfusion on coagulation in patients with beta thalassemia majoren_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorEker, İbrahim
dc.relation.journalBlood Coagulation and Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record