Vestibular involvement of PFAPA syndrome
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Objective: PFAPA syndrome is derived from the initials of the English words of the findings that make up the syndrome (“Periodic Fever”, “Aphthous Stomatitis”, “Pharyngitis”, “Adenitis”). This study aims to evaluate the vestibular system in patients with PFAPA syndrome by the cVEMP test and to give a general review of PFAPA syndrome in light of current literature. Methods: In this prospective study, 30 patients aged 4–6 who were diagnosed with PFAPA in a tertiary pediatrics clinic, between January 2016 and February 2020 and 30 children of the same age group who applied to a tertiary otorhinolaryngology clinic for other reasons and proven to have no hearing or vestibular problems were included and in addition to routine physical examination, electromyographic activity of the sternocleidomastoid muscle surface was measured. Results: We found that the amplitude difference between cVEMP p1-n1 in patients with PFAPA syndrome in both ears decreased compared to the healthy control group. Conclusion: Our study proves there is a vestibular system involvement of PFAPA syndrome. This study is the first in the literature to search the relationship between PFAPA and the vestibular system. © 2021 Elsevier Inc.