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dc.contributor.authorGül, Mehmet
dc.contributor.authorDündar, Serkan
dc.contributor.authorBozoğlan, Alihan
dc.contributor.authorÖzcan, Erhan Cahit
dc.contributor.authorTekin, Samet
dc.contributor.authorTalo Yıldırım, Tuğba
dc.contributor.authorKarasu, Necmettin
dc.contributor.authorBingül, Muhammet Bahattin
dc.identifier.citationGul, M., Dundar, S., Bozoglan, A., Ozcan, E. C., Tekin, S., Yildirim, T. T., ... & Bingul, M. B. (2022). Evaluation of the effects of the systemic proton pump inhibitor-omeprazole on periimplant bone regeneration and osseointegration: An experimental study. Journal of Oral Biology and Craniofacial Research.en_US
dc.description.abstractObjective Investigations of the effects of proton pump inhibitors (PPIs) on bone healing have revealed that they affect bone regeneration negatively. The exact mechanism by which this adverse effect on bone tissue is not known. The aim of this study is to biomechanic and biochemical investigation of the effects of the PPIs on guided periimplant bone regeneration. Material & methods Spraque dawley rats were divided controls (n = 8): there is no treatment during 8 week experimental period, PPI- Dosage 1 (n = 8) and Dosage 2 (n = 8): 5 mg/kg and 10 mg/kg omeprazol applied 3 times in a week with oral gavage during 8 weeks respectfully. Bone defects created half of the implant length circumferencial after implant insertion and defects filled with bone grafts. After experimental period the rats sacrified and implants with surrounding bone tissues were removed to reverse torque analysis (Newton), blood samples collected to biochemical analysis (glucose, AST, ALT, ALP, urea, creatinin, calcium, P). Results Biomechanic reverse torque values did not revealed any statistical differences between the groups (P > 0,05). Conclusion According the biomechanical and biochemical parameters PPIs does not effect the periimplant guided bone regeneration.en_US
dc.subjectProton pump inhibitorsen_US
dc.subjectGuided bone regenerationen_US
dc.subjectTibial boneen_US
dc.titleEvaluation of the effects of the systemic proton pump inhibitor-omeprazole on periimplant bone regeneration and osseointegration: An experimental studyen_US
dc.departmentAFSÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Plastik Rekonstrüktif ve Estetik Cerrahien_US
dc.contributor.institutionauthorKarasu, Necmettin
dc.relation.journalJournal of Oral Biology and Craniofacial Researchen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US

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