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dc.contributor.authorTurgutalp, Kenan
dc.contributor.authorCebeci, Egemen
dc.contributor.authorTürkmen, Aydın
dc.contributor.authorDerici, Ülver
dc.contributor.authorSeyahi, Nurhan
dc.contributor.authorEren, Necmi
dc.contributor.authorDede, Fatih
dc.contributor.authorGüllülü, Mustafa
dc.contributor.authorBaştürk, Taner
dc.contributor.authorManga Şahin, Gülizar
dc.contributor.authorYılmaz, Mürvet
dc.contributor.authorSipahi, Savaş
dc.contributor.authorŞahin, Garip
dc.contributor.authorUlu, Sena
dc.contributor.authorTatar, Erhan
dc.contributor.authorGündoğdu, Ali
dc.contributor.authorTuran Kazancıoğlu, Rümeyza
dc.contributor.authorSevinç, Can
dc.contributor.authorGüngör, Özkan
dc.contributor.authorŞahin, İdris
dc.contributor.authorKutlay, Sim
dc.contributor.authorKurultak, İlhan
dc.contributor.authorAydın, Zeki
dc.contributor.authorAltun, Bülent
dc.contributor.authorDursun, Belda
dc.contributor.authorYılmaz, Zülfikar
dc.contributor.authorUzun, Özcan
dc.contributor.authorSüleymanlar, Gültekin
dc.contributor.authorCandan, Ferhan
dc.contributor.authorSezer, Siren
dc.contributor.authorBaşak Tanburoğlu, Derya
dc.contributor.authorBiçik Bahçebaşı, Zerrin
dc.contributor.authorTaymez, Dilek
dc.contributor.authorAkçalı, Esra
dc.contributor.authorOygar, Deren
dc.contributor.authorİstemihan, Zülal
dc.contributor.authorBardak, Simge
dc.contributor.authorAkçay, Ömer Faruk
dc.contributor.authorDinçer, Mevlüt Tamer
dc.contributor.authorDervişoğlu, Erkan
dc.contributor.authorYenigün, Ezgi
dc.contributor.authorTürkmen, Kültigin
dc.contributor.authorÖztürk, Savaş
dc.identifier.citationTurgutalp, K., Cebeci, E., Turkmen, A., Derici, U., Seyahi, N., Eren, N., ... & Ozturk, S. (2021). The relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working group. BMC nephrology, 22(1), 1-8.en_US
dc.description.abstractBackground Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = − 0.084, r = − 0.102, r = − 0.006, r = 0.062, r = 0.014, r = − 0.044, r = − 0.061, r = − 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.en_US
dc.subjectIgA nephropathyen_US
dc.subjectGlomerular IgG stainingen_US
dc.subjectRenal prognostic factorsen_US
dc.titleThe relationship between glomerular IgG staining and poor prognostic findings in patients with IgA nephropathy: the data from TSN-GOLD working groupen_US
dc.departmentAFSÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorUlu, Sena
dc.relation.journalBMC Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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