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dc.contributor.authorGülyeşil, Furkan Fatih
dc.contributor.authorİnan, Sibel
dc.contributor.authorGobeka, Hamidu Hamisi
dc.contributor.authorSabaner, Mehmet Cem
dc.contributor.authorAlizada, Anar
dc.date.accessioned2022-05-16T12:02:17Z
dc.date.available2022-05-16T12:02:17Z
dc.date.issued23.03.2022en_US
dc.identifier.citationGulyesil, F. F., Inan, S., Gobeka, H. H., Sabaner, M. C., & Alizada, A. (2022). Retinal ultrastructural, electrophysiological, and microvascular morphological outcomes in diabetic macular edema treated with intravitreal bevacizumab. Irish Journal of Medical Science (1971-), 1-11.en_US
dc.identifier.issn1863-4362
dc.identifier.urihttps://doi.org/10.1007/s11845-022-02979-y
dc.identifier.urihttps://hdl.handle.net/20.500.12933/1018
dc.description.abstractBackground Investigation of retinal ultrastructural, electrophysiological, and microvascular morphological changes, as well as correlations between these changes and visual outcome in naïve diabetic macular edema (DME) patients after intravitreal bevacizumab therapy (IVBT). Methods This prospective interventional study enrolled 31 DME patients’ eyes treated with monthly IVBT for three months. Best-corrected visual acuity (BCVA) and intraocular pressure (IOP) were measured, and fundus fluorescein angiography, optical coherence tomography (OCT), microperimetry, as well as optical coherence tomography angiography (OCTA) were performed before and after IVBT. Patients were grouped based on BCVA improvement after three consecutive IVBT: group 1: > 10 letters, group 2: ≤ 5 letters, and group 3: between 6 and 10 letters. Results Mean BCVA increased significantly from 34.2 to 39.9 letters (p < 0.001). Central macular thickness decreased significantly from 335.1 to 276.4 μm (p < 0.001). Fixation stability, retinal sensitivity, and local deficit all improved significantly (p < 0.001 for all). There was no statistically significant change in IOP (p = 0.665). Although OCTA parameters did not change significantly, lower foveal avascular zone (FAZ) area, higher foveal vessel density 300 μm area around FAZ and deep plexus vascular density were associated with highly improved BCVA, retinal sensitivity, and local deficit. Also, there were no significant intergroup differences in gender, age, baseline BCVA, HbA1c, IOP, phakic/pseudophakic lens ratio, concomitant hypertension, and superficial capillary plexus vascular density. Conclusions IVBT was associated with significantly improved BCVA, retinal ultrastructural integrity, and electrophysiological patterns in naive DME patients. Improvements in retinal electrophysiology correlated with ultrastructural improvements, which could be predicted using OCTA.en_US
dc.language.isoengen_US
dc.publisherRoyal Academy of Medicine of Irelanden_US
dc.relation.isversionof10.1007/s11845-022-02979-yen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectDiabetic macular edemaen_US
dc.subjectIntravitreal bevacizumaben_US
dc.subjectMicroperimetryen_US
dc.subjectOptic coherence tomography angiographyen_US
dc.subjectVisual acuityen_US
dc.titleRetinal ultrastructural, electrophysiological, and microvascular morphological outcomes in diabetic macular edema treated with intravitreal bevacizumaben_US
dc.typearticleen_US
dc.authorid0000-0003-1015-409Xen_US
dc.authorid0000-0001-8332-2205en_US
dc.authorid0000-0003-3408-6167en_US
dc.departmentAFSÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göz Hastalıkları Ana Bilim Dalıen_US
dc.contributor.institutionauthorGülyeşil, Furkan Fatih
dc.contributor.institutionauthorİnan, Sibel
dc.contributor.institutionauthorAlizada, Anar
dc.identifier.startpage1en_US
dc.identifier.endpage11en_US
dc.relation.journalIrish Journal of Medical Scienceen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US


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