Relationship Between Blood Lipid Levels and Mortality in Hospitalized COVID-19 Patients
AuthorAydın, Sidar Şiyar
Tanboğa, İbrahim Halil
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CitationAydın, S. Ş., Aksakal, E., Aydınyılmaz, F., Gülcü, O., Saraç, İ., Kalkan, K., ... & Tanboğa, İ. H. (2022). Relationship Between Blood Lipid Levels and Mortality in Hospitalized COVID-19 Patients. Angiology, 00033197211072346.
People with comorbid conditions are at increased risk of developing severe/fatal coronavirus disease 2019 (COVID-19). We aimed to investigate the relationship between lipid levels and mortality in patients hospitalized for COVID-19 infection. In this retrospective study, we collected the details of 5274 COVID-19 patients who were diagnosed using the polymerase chain reaction and/or computed tomography and were hospitalized between March and November 2020. Patients (n = 4118) whose blood lipid levels were checked within the first 24 h after hospitalization were included in the study. Multivariable cox proportional hazards regression was used to assess the relationship between lipid variables such as low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) and death. There was a statistically significant association between LDL-C, HDL-C, and TG levels and the risk of death (P =.002, <.001, and .035, respectively). Low and high LDL-C, low HDL-C, and high TG levels were negatively associated with COVID-19-related mortality. Blood lipid levels may be useful predictors of mortality in COVID-19 patients.